Acne vulgaris is a common skin disorder affecting almost 60 to 70% of the population across the world. Almost 20% of the cases of acne vulgaris result in severe scarring leading to permanent disfigurement. This condition is characterized by the formation of open or closed comedones on the skin along with non-inflammatory or inflammatory papules, nodules and pustules. The parts of the skin most commonly affected with this disorder are the face, the back and the upper part of the chest, due to the dense population of sebaceous glands in these parts. Proper treatment of this condition by using powerful topical agents like Azelex can help in clearing these skin lesions completely. The common causes of acne vulgaris are given below:
Heredity: a history of acne vulgaris in the parents makes the children more prone to developing these skin lesions. This condition is passed on from generation to generation in an autosomal dominant pattern. Acne vulgaris may also skip a generation.
Gender: this condition is more common in men than in women during adolescence. But, during adulthood, it is more likely to affect women than men.
Race: it is common in North American, African American and Spanish people.
Age: though this condition can affect people of all ages, its incidence is higher in adolescents. Newborns infants can have inflammatory patches on the skin due to the influence of maternal hormones on their skin. However, the lesions resolve spontaneously within few weeks after birth.
Cosmetics: improper use of cosmetics can increase the risk of acne vulgaris.
Medicines: some medicine like steroids, iodides and anti-epileptics can promote the development of acne.
Sunlight: excessive exposure to the sunlight can lead to acne vulgaris. It can also aggravate the previously existing skin lesions. However, these skin lesions clear up completely once patients buy Azelex cream and start using it as recommended.
Pathogenesis of acne vulgaris
Retention hyperkeratosis is the first event in the development of skin lesions of acne vulgaris. The exact cause of the hyper-proliferation is still not known. It has been postulated that the increased production of androgens can be responsible for triggering the proliferation. Excessive production of sebum is also suspected to have a role in the development of acne vulgaris. According to some scientists, an anaerobic organism called P acnes is suspected to be responsible for this condition. P acnes can promote the inflammation of the skin by increasing the production of pro-inflammatory mediators. This organism can also activate some receptors on neutrophils and monocytes leading to the production of multiple cytokines. This further aggravates the inflammation of the skin.
Generic Azelex is a topical agent that is highly effective for the treatment of acne vulgaris. The active ingredient of this medication is Azelaic Acid, which helps in normalizing the keratinization process of the skin cells. Thus, it helps in getting rid of the skin lesions by tackling their root cause. Azelex has strong antimicrobial properties. It helps in getting rid of the organisms responsible for the lesions. Patients should apply generic Azelex on the affected patches, 2 times in a day. This cream helps patients in getting rid of the ugly skin lesions within 4 to 6 weeks of beginning to use it.